First robust genetic links to depression emerge.Flint has proved himself wrong. In Nature this week, his team reports2 the first two genetic markers reproducibly linked to major depressive disorder, one of the leading causes of disability globally. The findings could guide biologists to new drugs, and could one day be used to aid diagnosis. But many in the field are excited that the markers have been unearthed at all. The results look set to end years of debate over whether sequences for such a complex disorder could be found — and Flint’s study may serve as a framework for future attempts to collect data from tens of thousands of people.